Growth Hormone (HGH) Replaces GH directly Bypasses pituitary regulation Can suppress endogenous GH production May raise IGF-1 excessively Higher risk of edema, insulin resistance, and carpal tunnel syndrome Tesamorelin Stimulates the pituitary gland Preserves physiologic pulsatility Maintains feedback control Lower risk of GH excess Improves IGF-1 within normal ranges From a functional medicine standpoint, tesamorelin is a restorative therapy , whereas HGH is a replacement therapy
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Unlike full-length growth hormone, AOD-9604 does not upregulate IGF-1, does not induce insulin resistance in reported toxicology models, and does not measurably affect linear growth in adult animal models
Have certain eye diseases such as wet macular degeneration, diabetic retinopathy, or macular edema